Serotonin and amyloid deposition: A link between depression and Alzheimer’s disease?

نویسندگان

چکیده

Abstract Indirect agonism has been invoked as part of the mechanism antipsychotic action at dopamine D 2/3 receptors, and more recently a salient neuropharmacological aspect serotonin 5‐HT 2A drug pimavanserin (Pim). We now comment on an article in this volume showing that Pim treatment attenuates deposition Aβ protein brain transgenic Alzheimer's disease model mice. may interfere with by shifting balance between two signaling pathways, is, antagonism G q/11 αi1 signaling. Treatment serotonin‐selective reuptake inhibitors (SSRIs) evoked also reduced amyloid mice, but SSRI does not unequivocally progression human disease, perhaps because complex effects chronic multiple receptor types. Preclinical findings suggest promising pharmacological strategy for intervening against pathology, very early stage disease. However, much remains to be learned about convergence various receptor‐mediated pathways final common path leading net deposition. image

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ژورنال

عنوان ژورنال: Journal of Neurochemistry

سال: 2021

ISSN: ['0022-3042', '1471-4159']

DOI: https://doi.org/10.1111/jnc.15269